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Since the onset of the HIV/AIDS pandemic in 1981 cases of people with a natural immunity to HIV have been documented. Although these persons, called long-term non-progressors (LTNPs) are infected with HIV, they never develop AIDS. When LTNPs are infected, some suffer an initial drop Sistema de Tratamiento Natural Para el Vitíligo in their T-4 (CD4) cell count. However, when their T-4 (CD4) cell count reaches around 500 it stabilizes and never drops again preventing the onset of AIDS. Furthermore, while CD8+ T-Cells (even in large numbers) are ineffective against HIV-infected T-4 (CD4) cells in progressors (persons without a natural immunity to HIV), the National Institutes of Health (NIH) reported in a December 4, 2008 press release that "CD8+ T-Cells taken from LTNPs [can efficiently] kill HIV-infected cells in less than [an] hour" in which "a protein, perforin (produced only in negligible amounts in progressors), manufactured by their CD8+ T-Cells punches holes in the infected cells" enabling a second protein, "granzyme B" to penetrate and kill them.