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Which changes occur with aging?

It is understood that aging generates a lot of changes within the individual: weight changes, decrease in neurotransmitters, hormonal changes, change in sleep structure, weakening of the immune system, more or less chronic fatigue, decrease in endurance, loss visual acuity, withdrawal from social life, not to mention cognitive problems and difficulty concentrating. An aging person will be weakened. It therefore becomes obvious that the effect of the medicines will be impaired. Based on the factors listed above, one can easily think of changes about drug absorption (which in general will be delayed or decreased), distribution (changed), metabolism (decreased) and elimination (decreased).
https://www.globenewswire.com/news-release/2020/12/23/2149750/0/en/peak-...