tanzeelbis's blog

Human identification is widely used in forensics, paternity testing, disaster victim identification, and anthropology, among other applications, with DNA analysis/profiling being a key tool in this sector. Due to increasing demands on time and resources, human identification and forensics labs are under constant pressure to increase the efficiency of their workflows without sacrificing quality. Examining the variety of biological indicators that are available to investigators illustrates the basic principles of each process in criminal investigation and paternity identification.

The advent of Next-Generation Sequencing (NGS) has revolutionized the field of genomics, enabling researchers to sequence DNA and RNA at an unprecedented scale. NGS technologies generate vast amounts of data, posing significant challenges in terms of storage, management, and analysis. In this blog, we will explore the challenges associated with NGS data storage and discuss the innovative solutions that have emerged to address this critical aspect of genomic research.

The Data Deluge

Programmed cell death 1 (PD-1) and programmed death ligand 1 (PD-L1) are checkpoint proteins on immune cells responsible for the induction and maintenance of immune tolerance within the tumor microenvironment. Research studies have found that tumors tend to evade host defense mechanisms using these PD-1/PDL-1 pathways. PD-1/PDL-1 interaction act by inhibiting this binding and preventing tumor cells from escaping, ultimately leading to the destruction of cancer cells.

In recent years, gene editing technologies have emerged as a promising tool for treating a variety of genetic disorders. These technologies have the potential to not only cure genetic diseases but also to enhance human abilities, modify food crops, and create new species altogether. However, as with any powerful tool, gene editing also raises ethical and social questions. In this blog, we will explore the various gene editing technologies and their potential applications, as well as the ethical and social implications of their use.

What is Gene Editing?

Major commercial research initiatives undertaken or funded by leading players in the market have leveraged findings from the global research initiatives, leading to a massive scope for genetic engineering, genome sequencing services, and their commercialization. The organizations are conveying organic and inorganic growth strategies to contend and compete in the market.

Organ transplantation is a medical procedure that involves removing an organ from a donor and placing it into a recipient who has a damaged or failed organ. This procedure is often a last resort for patients who have exhausted all other treatment options, and it can be life-saving. However, organ transplantation is a complex and risky procedure that requires careful diagnosis, evaluation, and matching to ensure that the organ will be accepted by the recipient's body and will function properly. This is where organ transplant diagnostics come in.

Cell-based assays are powerful tools used in the pharmaceutical, biotechnology, and academic research fields to investigate various biological processes. These assays are designed to study the interaction between drugs or other chemical compounds with living cells. The information obtained from cell-based assays is critical for drug discovery, toxicity screening, and basic research. In this blog post, we will discuss cell-based assays in detail, including their types, advantages, and limitations.

What is a Cell-Based Assay?

Cancer is a complex and heterogeneous disease, and early detection is critical for improving patient outcomes. The traditional approach to cancer screening involves targeting a single type of cancer in a specific population. However, recent advances in genomic medicine and technology have paved the way for a new approach to cancer screening: multicancer screening.

Endoscopy has been used as a procedure to explore and visualize the interiors of the human body since the early 1800s. In 1805, Bozzini, a German physician, used a ‘lichtleiter’ to examine the genitourinary (GU) tract. Later, in 1855, another physician named Desormeaux added a light source using a light lamp for better visualization. With time, endoscopes witnessed many advancements for better diagnostic and therapeutic purposes. Earlier, rigid endoscopes made up of metal tubes were used for gastroscopy, but the light source was inadequate to perform the procedure.

According to the World Health Organization (WHO), the uncontrolled growth and spread of chronic diseases have created a great discrepancy in the life expectancy rate, and this is mainly due to a lack of diagnostics. More than one-third of total deaths are because of the absence of a proper first line of defense, i.e., diagnosis of the disease. In regard to in-vitro diagnostic (IVD) products, digital polymerase chain reaction (d-PCR) has done significantly great work, along with the process of innovation and evolution in d-PCR technology.