Rhinovirus is responsible for the majority of asthma exacerbations. The treatment of asthma exacerbations at the moment is insufficient. There is no evidence that macrolide antibiotics cause asthma exacerbations. However, there has been some research.
The anti-rhinoviral properties of macrolides were investigated by inducing antiviral gene protein and mRNA. Pre-treatment of primary human bronchial epithelial cell lines with Azee 500 , Erythromycin and Telithromycin was done before infecting them with minor-group rhinovirus 1B or major-group rhinovirus 16 The mRNA expression of the antiviral genes, type I interferon-b and type III interferon-l1, interferon-l2/3, and interferon-stimulated genes (retinoic acid inducible gene I, melanoma differentiation associated gene 5, oligoadenylate synthase, MA and viperid) and pro-inflammatory cytokines (interleukin (IL)-6 and IL-8), and rhinovirus replication and release were measured.
Azee 500 , but not erythromycin or telithromycin, significantly increased rhinovirus 1B- and rhinovirus 16-induced interferons and interferon-stimulated gene mRNA expression and protein production. Azee 500 also significantly decreased rhinovirus replication and released. Azee 500 pretreatment did not reduce the rhinovirus-induced IL-6, IL-8 protein or mRNA expression.
In conclusion, the results demonstrate that Azee 500 has anti-rhinoviral activity in bronchial epithelial cells and, during rhinovirus infection, increases the production of interferon-stimulated genes.
Azee 500 Tablet is an antibacterial medication that can be used to treat bacterial infections of the nose, throats, tonsils, ears and skin. It prevents the growth of proteins necessary for bacterial growth. It prevents further bacterial growth and increase.
Side effects of Azee 500 Tablet include stomach pain, nausea, diarrhea, brain swelling, queasiness and cerebral pain. If you have side effects such as skin rash, swelling/expansion of the face/throat/tongue or trouble breathing, seek out a qualified physician immediately.
Your PCP may recommend that Azee 500 Tablet be taken with or without food. In a few days, you will notice a difference in your mood. You should continue to take this medication for the recommended duration. If you skip a dose or fail to follow through on treatment, there is a greater chance of recontamination. This would make it difficult to treat. This medicine can only be used to treat microbe-caused contaminations, not parasites or infections.